Emotional Side Effects of Infertility Medications

Learn about the potential side effects of the most common infertility medication & the ways you can cope.

Infertility, affecting many couples, can have a number of mental health complications like depression (see my article on Psychological Impact of Infertility). The most common treatment medications can themselves also have effects on a woman’s emotional state.

Clomiphene (clomid) and hMG

One of the most commonly prescribed medication in infertility treatment is clomiphene. Clomiphene is a medication used to treat ovulation problems, a common reason for infertility. It works by affecting a gland in the brain, the hypothalamus, leading it to trigger the pituitary gland to release the hormones LH (luteinizing hormone) and FSH (follicle stimulating hormone), both of which are essential to the ovulation cycle. Another treatment is human menopausal gonadotrophin (hMG), which stimulates ovarian function.

Physical side effects from these medications are well known, including symptoms of hot flashes or vision changes for example, but the emotional side effects are less discussed. Women taking this medication have described feeling out of control or out of touch with reality. Others have described problems with sleep and insomnia, irritability and anxiety, and in rare cases psychosis.

A study in 2005 found that 40% of women taking clomiphene and 60% of those taking hMG experienced psychological side effects including mood swings, irritability, and feeling down. It can be a challenge to know which of these symptoms are a function of the medication, the underlying condition of infertility and its association with mood and anxiety problems, or a co-occurring mental health issue. For this reason, it is not surprising that mental health concerns might go undetected and unaddressed.

Oral contraceptives

It may be surprising that oral contraceptives can help in the treatment of infertility, but they are used often in IVF. These particular formulations have higher doses of progesterone, which has been associated with increased depression.

GnRH Agonists

These medication suppress ovarian hormones, and are therefore used commonly to treat conditions such as endometriosis. In fertility treatment, they are used in conjunction with IVF to decrease luteinizing hormone (one of the gonadal hormones; see my article on Hormones in Pregnancy). The most common psychiatric side effects of taking these medications include depression, emotional lability, and changes in libido.

There are long articles detailing several theories about the mechanism behind the development of the mood symptoms, related to changes in hormones such as estrogen, which are beyond the scope of this article. However, the good news is that these same studies also note that the symptoms respond well to treatment, such as serotonergic antidepressant medications like sertraline (brand name Zoloft).

Take-Home Points

Given that fertility treatment involves medications that modify hormones, it is not surprising that it is associated with mood changes. Since going through fertility treatment is itself an emotionally difficult process, it is also not surprising that women going through the process are already vulnerable to these mood changes. If you are struggling with some of those common side effects such as depression, several important steps can be taken.

  • The first is to make sure that your treating provider – whether that is an ob/gyn or reproductive endocrinologist – is aware of this. It could mean you need a dose adjustment or a revision of the treatment plan.
  • Next, consider engaging with a mental health professional. That could mean a psychotherapist or it could be a psychiatrist who would be able to discuss medication treatment options. There are several recommended for women in the process of conception (see article on Medication Safety Review Series on SSRIs, for example).
  • Finally, consider sharing with others in to make sure you have a strong support system. That could mean other women going through infertility treatment, your partner and family members, or even online communities.

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Choi, S-H. et. al. Psychological side-effects of clomiphene citrate and human menopausal gonadotrophin. Journal of Psychosomatic Obstetrics & Gynecology (2005) 26(2): 93-100.

Warmock, J.K. et. al. Depressive mood symptoms associated with ovarian suppression. Fertility and Sterility. (2000) 74(5): 984-6.
Wilkins, K.M, Warnock, J.K., Serrano, E. Depressive Symptoms related to infertility and infertility treatments. Psychiatric Clin N Am 33 (2010) 309-321.

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You deserve an emotionally healthy & rewarding pregnancy! I started Mind Body Pregnancy to provide you with expert guidance on mental wellness during pregnancy and postpartum. My background as a Harvard-trained clinician with current joint appointments at OB/GYN & Reproductive Psychiatry at UCSF Medical Center enable me to be your partner and guide.